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In Vivo Diagnostics - Indigo Carmine

abp has agreements to market internationally two injectable dyes: Indigo Carmine and Indocyanine Green (IC Green formerly known as Cardio Green). The dyes are used extensively as diagnostic tools in a number of medical applications.

Indigo Carmine is used in:

NEW - Contrast Staining in Colonoscopy

MINIMIZE THE RISK OF NOT DETECTING DYSPLASIA IN ULCERATIVE COLITIS

This application was the subject of a recent article published in Gut 2004;53:256-260, entitled "Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis".

In its "DISCUSSION", this paper suggests that "careful mucosal examination aided by pancolonic chromoendoscopy and targeted biopsies of suspicious lesions may be a more effective surveillance methodology than taking multiple non-targeted biopsies".

CHROMOENDOSCOPY DOES NOT PROLONG THE PROCEDURE
"In the study, a dye spray extubation with targeted biopsies took the same time as a standard extubation with multiple non targeted biopsies".

INDIGO CARMINE DYE SPRAYING OF THE WHOLE COLON IS SAFE
"... and in terms of dysplasia detection may be more time effective than taking large numbers of non-targeted biopsies".

THERE WAS A STRONG STATISTICAL TREND TOWARDS AN INCREASE IN DYSPLASIA DETECTION WITH INDIGO CARMINE DYE SPRAYING
"... With regard to dysplasia detection, the non–targeted biopsy protocol (2904 biopsies) detected no dysplasia from 100 patients, the pre-dye spray targeted biopsy protocol (43 biopsies) detected two dysplastic lesions in two of the 100 patients, and the dye spray targeted biopsy protocol (114 biopsies) detected these two dysplastic lesions plus seven additional dysplastic lesions in five more of the 100 patients".

Indigo Carmine is available in packs of 10 x 5 ml ampules. Each ampule contains 5ml of a 0.8% solution of indigo carmine.